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Role of MEKK2-MEK5 in the regulation of TNF-α gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells

Cross-linking of the high-affinity IgE receptor (FcɛRI) on mast cells with IgE and multivalent antigen triggers mitogen-activated protein (MAP) kinase activation and cytokine gene expression. We report here that MAP kinase kinase 4 (MKK4) gene disruption does not affect either MAP kinase activation...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Chayama, Kosuke, Papst, Philip J., Garrington, Timothy P., Pratt, Joanne C., Ishizuka, Tamotsu, Webb, Saiphone, Ganiatsas, Soula, Zon, Leonard I., Sun, Weiyong, Johnson, Gary L., Gelfand, Erwin W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274363/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081021898
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