Prolonged Mitogen-Activated Protein Kinase Kinase (MEK) Inhibition Induces Increase in Proteolysis and Compensatory Phosphorylation of MEK and Protein Kinase B (AKT) in Plexiform Neurofibroma Cells

Plexiform neurofibromas associated with neurofibromatosis type I (pNF1s) are benign tumors caused by the complete loss of function of the <i>NF1</i> gene, which encodes a negative regulator of the RAS/mitogen-activated protein kinase (MAPK) pathway. pNF1s carry a significant risk of progression to m...

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Principais autores:	Kyungmin Ji, John F. Callaghan, Thomas J. Ridella, Raymond R. Mattingly
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2026-02-01
Serier:	Cells
Fag:	plexiform neurofibroma mitogen-activated protein kinase kinase (MEK) inhibition proteolysis MEK protein kinase B (AKT)
Online adgang:	https://www.mdpi.com/2073-4409/15/5/434
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