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MEK kinase 1 gene disruption alters cell migration and c-Jun NH(2)-terminal kinase regulation but does not cause a measurable defect in NF-κB activation

MEK kinase 1 (MEKK1) is a 196-kDa mitogen-activated protein kinase (MAPK) kinase kinase that, in addition to regulating the c-Jun NH(2)-terminal kinase (JNK) pathway, is involved in the control of cell motility. MEKK1(−/−) mice are defective in eyelid closure, a TGFα-directed process involving the m...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Yujiri, Toshiaki, Ware, Margaret, Widmann, Christian, Oyer, Ryan, Russell, David, Chan, Edward, Zaitsu, Yuzuru, Clarke, Penny, Tyler, Kenneth, Oka, Yoshitomo, Fanger, Gary R., Henson, Peter, Johnson, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16535/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10852963/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.130176697
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