Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity
Here, we disrupted the p70 S6 kinase (p70(s6k)) gene in murine embryonic stem cells to determine the role of this kinase in cell growth, protein synthesis, and rapamycin sensitivity. p70(s6k−/−) cells proliferated at a slower rate than parental cells, suggesting that p70(s6k) has a positive influenc...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1998
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560223/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.5033 |
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