MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

Ligation of the high-affinity IgE receptor (FcεRI) or of c-Kit stimulates cytokine production in mast cells. We show that MEK kinase 2 (MEKK2), a MAPK kinase kinase (MAP3K) that regulates the JNK and ERK5 pathways, is required for cytokine production in embryonic stem (ES) cell-derived mast cells (E...

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Main Authors: Garrington, Timothy P., Ishizuka, Tamotsu, Papst, Philip J., Chayama, Kosuke, Webb, Saiphone, Yujiri, Toshiaki, Sun, Weiyong, Sather, Sue, Russell, David M., Gibson, Spencer B., Keller, Gordon, Gelfand, Erwin W., Johnson, Gary L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC314024/
https://ncbi.nlm.nih.gov/pubmed/11032806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.20.5387
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