Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes

The antitumor effect of adoptively transferred tumor-specific cytotoxic T lymphocytes (CTLs) is impaired by the limited capacity of these cells to expand within the tumor microenvironment. Administration of interleukin 2 (IL-2) has been used to overcome this limitation, but the systemic toxicity and...

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Bibliografiske detaljer
Main Authors: Quintarelli, Concetta, Vera, Juan F., Savoldo, Barbara, Giordano Attianese, Greta M. P., Pule, Martin, Foster, Aaron E., Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Dotti, Gianpietro
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Plenary Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2018664/
https://ncbi.nlm.nih.gov/pubmed/17638856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-072843
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