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Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts
BACKGROUND: Transforming growth factor-β1 (TGF-β1), a key biological mediator following ionizing radiation, plays a role in a complex tissue reaction involved in local radiation-induced pathological damage. Knocking out Smad3 (S3KO), a downstream signaling intermediate in the TGF-β pathway, in mice...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2016790/ https://ncbi.nlm.nih.gov/pubmed/17624738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2007.05.012 |
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