Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts

BACKGROUND: Transforming growth factor-β1 (TGF-β1), a key biological mediator following ionizing radiation, plays a role in a complex tissue reaction involved in local radiation-induced pathological damage. Knocking out Smad3 (S3KO), a downstream signaling intermediate in the TGF-β pathway, in mice...

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Bibliografski detalji
Glavni autori: Arany, Praveen R., Flanders, Kathleen C., DeGraff, William, Cook, John, Mitchell, James B., Roberts, Anita B.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2016790/
https://ncbi.nlm.nih.gov/pubmed/17624738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2007.05.012
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