Absence of ERK5/MAPK7 delays tumorigenesis in Atm(−/−) mice

Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis. MAPK7 has been implicated in numero...

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Vydáno v:Oncotarget
Hlavní autoři: Granados-Jaén, Alba, Angulo-Ibáñez, Maria, Rovira-Clavé, Xavier, Gamez, Celina Paola Vasquez, Soriano, Francesc X., Reina, Manuel, Espel, Enric
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342677/
https://ncbi.nlm.nih.gov/pubmed/27793024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12908
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