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Absence of ERK5/MAPK7 delays tumorigenesis in Atm(−/−) mice
Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis. MAPK7 has been implicated in numero...
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| Pubblicato in: | Oncotarget |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals LLC
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342677/ https://ncbi.nlm.nih.gov/pubmed/27793024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12908 |
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