Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo

BACKGROUND AND PURPOSE: The chemokine receptor CCR1 is a potential target for the treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental arthritis and the underlying mechanisms, we used J-113863, a non-peptide antagonist of the mouse receptor. EXPERIMENTAL APPROACH...

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Detalhes bibliográficos
Main Authors: Amat, M, Benjamim, C F, Williams, L M, Prats, N, Terricabras, E, Beleta, J, Kunkel, S L, Godessart, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014657/
https://ncbi.nlm.nih.gov/pubmed/17016504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706912
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