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Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo
BACKGROUND AND PURPOSE: The chemokine receptor CCR1 is a potential target for the treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental arthritis and the underlying mechanisms, we used J-113863, a non-peptide antagonist of the mouse receptor. EXPERIMENTAL APPROACH...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014657/ https://ncbi.nlm.nih.gov/pubmed/17016504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706912 |
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