Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis

BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model. METHODOLOGY/PRINCIPAL FINDINGS: Monocytes from healt...

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Detalhes bibliográficos
Main Authors: Lebre, Maria C., Vergunst, Clarissa E., Choi, Ivy Y. K., Aarrass, Saïda, Oliveira, Ana S. F., Wyant, Tim, Horuk, Richard, Reedquist, Kris A., Tak, Paul P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128605/
https://ncbi.nlm.nih.gov/pubmed/21747955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021772
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