Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy

AIMS: To study the population pharmacokinetics of thioTEPA and its main metabolite TEPA in patients receiving high-dose chemotherapy consisting of thioTEPA (80–120 mg m(−2) day(−1)), cyclophosphamide (1000–1500 mg m(−2) day(−1)) and carboplatin (265–400 mg m(−2) day(−1)) for 4 days. METHODS: ThioTEP...

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Autores principales: Huitema, Alwin D R, Mathôt, Ron A A, Tibben, Matthijs M, Schellens, Jan H M, Rodenhuis, Sjoerd, Beijnen, Jos H
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014425/
https://ncbi.nlm.nih.gov/pubmed/11167666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01301.x
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