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Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

AIMS: The cytochrome P450 enzyme CYP1A2 metabolises several drugs and carcinogens. We wanted to determine how much of the variability of CYP1A2 activity is explained by a newly discovered gene polymorphism in intron 1. METHODS: A single nucleotide polymorphism in intron 1 of the CYP1A2 gene at posit...

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Hlavní autoři: Sachse, Christoph, Brockmöller, Jürgen, Bauer, Steffen, Roots, Ivar
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014233/
https://ncbi.nlm.nih.gov/pubmed/10233211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00898.x
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