Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism

AIM: Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described. METHODS: From genomic DNA, 114 British Caucasians (49 colorectal cancer cases and 6...

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Bibliographische Detailangaben
Hauptverfasser: Sachse, Christoph, Bhambra, Upinder, Smith, Gillian, Lightfoot, Tracy J, Barrett, Jennifer H, Scollay, Jenna, Garner, R Colin, Boobis, Alan R, Wolf, C Roland, Gooderham, Nigel J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2003
Schlagworte:
Pharmacogenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884179/
https://ncbi.nlm.nih.gov/pubmed/12534642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01733.x
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