Mutations in the DNA Mismatch Repair Proteins MutS and MutL of Oxazolidinone-Resistant or -Susceptible Enterococcus faecium

Mutations in mutS and mutL, which encode DNA mismatch repair (MMR) proteins, can confer hypermutator phenotypes and may facilitate the emergence of mutational antibiotic resistance in bacteria. Linezolid-resistant enterococci (LRE) rarely emerge during therapy and contain mutations in 23S rRNA genes...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Willems, Rob J., Top, Janetta, Smith, Derek J., Roper, David I., North, Sarah E., Woodford, Neil
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC201155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14506009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.10.3061-3066.2003
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