Stable insertion of Alzheimer Aβ peptide into the ER membrane strongly correlates with its length

Alzheimer’s disease is characterized by the deposition of amyloid β-peptide (Aβ) plaques in the brain. Full-length amyloid-β precursor protein (APP) is processed by α- and β-secretases to yield soluble APP derivatives and membrane-bound C-terminal fragments, which are further processed by γ-secretas...

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Hauptverfasser: Lundin, Carolina, Johansson, Sofia, Johnson, Arthur E., Näslund, Jan, von Heijne, Gunnar, Nilsson, IngMarie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000821/
https://ncbi.nlm.nih.gov/pubmed/17659280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.07.003
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