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Stable insertion of Alzheimer Aβ peptide into the ER membrane strongly correlates with its length
Alzheimer’s disease is characterized by the deposition of amyloid β-peptide (Aβ) plaques in the brain. Full-length amyloid-β precursor protein (APP) is processed by α- and β-secretases to yield soluble APP derivatives and membrane-bound C-terminal fragments, which are further processed by γ-secretas...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000821/ https://ncbi.nlm.nih.gov/pubmed/17659280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.07.003 |
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