Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors

Fragile X syndrome (FXS), a common inherited form of mental retardation, is caused by the functional absence of the fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates the translation of specific mRNAs at synapses. Altered synaptic plasticity has been described in a mo...

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Bibliografiska uppgifter
Huvudupphovsmän: Nakamoto, Mika, Nalavadi, Vijayalaxmi, Epstein, Michael P., Narayanan, Usha, Bassell, Gary J., Warren, Stephen T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2007
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000537/
https://ncbi.nlm.nih.gov/pubmed/17881561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707484104
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