Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP), which represses and reversibly regulates the translation of a subset of mRNAs in dendrites. Protein synthesis can be rapidly stimulated by mGluR-induced and protein phosphatase 2a (PP2A)-mediated dephosphorylati...

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מידע ביבליוגרפי
Main Authors: Nalavadi, Vijayalaxmi C., Muddashetty, Ravi S., Gross, Christina, Bassell, Gary J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Society for Neuroscience 2012
נושאים:
Brief Communications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427762/
https://ncbi.nlm.nih.gov/pubmed/22357842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5057-11.2012
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