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Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species
Reduced capacity to produce ROS increases the severity of T cell–dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot exert oxidative burst, we hypothesized that T cell responsiveness is downregulated by ROS produced by...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1994618/ https://ncbi.nlm.nih.gov/pubmed/17909630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31935 |
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