Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

Reduced capacity to produce ROS increases the severity of T cell–dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot exert oxidative burst, we hypothesized that T cell responsiveness is downregulated by ROS produced by...

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Main Authors: Gelderman, Kyra A., Hultqvist, Malin, Pizzolla, Angela, Zhao, Ming, Nandakumar, Kutty Selva, Mattsson, Ragnar, Holmdahl, Rikard
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2007
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994618/
https://ncbi.nlm.nih.gov/pubmed/17909630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31935
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