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T cell surface redox levels determine T cell reactivity and arthritis susceptibility

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. W...

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Main Authors: Gelderman, Kyra A., Hultqvist, Malin, Holmberg, Jens, Olofsson, Peter, Holmdahl, Rikard
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1568933/
https://ncbi.nlm.nih.gov/pubmed/16908843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604571103
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