Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser(307) via distinct pathways

Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but the relevant phosphorylation sites are difficult to identify in cultured cells and to validate in isolated tissues. Recently, we discovered that recombinant NH(2)-terminal Jun kinase phosphorylates IRS-1 at Ser(307), whic...

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Bibliografiset tiedot
Päätekijät: Rui, Liangyou, Aguirre, Vincent, Kim, Jason K., Shulman, Gerald I., Lee, Anna, Corbould, Anne, Dunaif, Andrea, White, Morris F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2001
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC199174/
https://ncbi.nlm.nih.gov/pubmed/11160134
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