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Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser(307) via distinct pathways
Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but the relevant phosphorylation sites are difficult to identify in cultured cells and to validate in isolated tissues. Recently, we discovered that recombinant NH(2)-terminal Jun kinase phosphorylates IRS-1 at Ser(307), whic...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Clinical Investigation
2001
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC199174/ https://ncbi.nlm.nih.gov/pubmed/11160134 |
| टैग : |
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