Myosin motor Myo1c and its receptor NEMO/IKK-γ promote TNF-α–induced serine(307) phosphorylation of IRS-1

Tumor necrosis factor-α (TNF-α) signaling through the IκB kinase (IKK) complex attenuates insulin action via the phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser(307). However, the precise molecular mechanism by which the IKK complex phosphorylates IRS-1 is unknown. In this study, we r...

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Autors principals: Nakamori, Yoshitaka, Emoto, Masahiro, Fukuda, Naofumi, Taguchi, Akihiko, Okuya, Shigeru, Tajiri, Michiko, Miyagishi, Makoto, Taira, Kazunari, Wada, Yoshinao, Tanizawa, Yukio
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063884/
https://ncbi.nlm.nih.gov/pubmed/16754954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200601065
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