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Initial TCR-transgenic precursor frequency dictates critical aspects of the CD8 T cell response to infection

Adoptive transfer experiments with relatively large input numbers (~10(6)) of TCR-transgenic T-cells are widely used to model endogenous T-cell responses to infection or immunization. Here, we show that input numbers of naïve TCR-tg T cells sufficient to squelch the endogenous response to the same e...

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Detalhes bibliográficos
Main Authors: Badovinac, Vladimir P., Haring, Jodie S., Harty, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1989155/
https://ncbi.nlm.nih.gov/pubmed/17555991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.04.013
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