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Epitope specificity of memory CD8 T-cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice()
Perforin-deficient mice serve as models for familial hemophagocytic lymphohistiocytosis (FHL), a uniformly fatal disease associated with viral infection of perforin-deficient humans. Naïve perforin-deficient (PKO) BALB/c mice survive while vaccinated PKO mice containing virus-specific memory CD8 T-c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650624/ https://ncbi.nlm.nih.gov/pubmed/22678903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142263 |
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