Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a panel of primary human colorectal cancer samples, we...

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Main Authors: Schuebel, Kornel E, Chen, Wei, Cope, Leslie, Glöckner, Sabine C, Suzuki, Hiromu, Yi, Joo-Mi, Chan, Timothy A, Neste, Leander Van, Criekinge, Wim Van, van den Bosch, Sandra, van Engeland, Manon, Ting, Angela H, Jair, Kamwing, Yu, Wayne, Toyota, Minoru, Imai, Kohzoh, Ahuja, Nita, Herman, James G, Baylin, Stephen B
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988850/
https://ncbi.nlm.nih.gov/pubmed/17892325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030157
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