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Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

Gremlin1 (GREM1), a bone morphogenetic protein antagonist and putative angiogenesis-modulating gene, is silenced by promoter hypermethylation in human malignancies. Here we study GREM1 methylation in clear cell renal cell carcinoma (ccRCC) and its impact on tumor characteristics and clinical outcome...

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Detalhes bibliográficos
Main Authors: van Vlodrop, Iris J.H., Baldewijns, Marcella M.L., Smits, Kim M., Schouten, Leo J., van Neste, Leander, van Criekinge, Wim, van Poppel, Hein, Lerut, Evelyne, Schuebel, Kornel E., Ahuja, Nita, Herman, James G., de Bruïne, Adriaan P., van Engeland, Manon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808066/
https://ncbi.nlm.nih.gov/pubmed/20042676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090442
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