Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

Gremlin1 (GREM1), a bone morphogenetic protein antagonist and putative angiogenesis-modulating gene, is silenced by promoter hypermethylation in human malignancies. Here we study GREM1 methylation in clear cell renal cell carcinoma (ccRCC) and its impact on tumor characteristics and clinical outcome...

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Hlavní autoři: van Vlodrop, Iris J.H., Baldewijns, Marcella M.L., Smits, Kim M., Schouten, Leo J., van Neste, Leander, van Criekinge, Wim, van Poppel, Hein, Lerut, Evelyne, Schuebel, Kornel E., Ahuja, Nita, Herman, James G., de Bruïne, Adriaan P., van Engeland, Manon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808066/
https://ncbi.nlm.nih.gov/pubmed/20042676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090442
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