Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma

Gremlin1 (GREM1), a bone morphogenetic protein antagonist and putative angiogenesis-modulating gene, is silenced by promoter hypermethylation in human malignancies. Here we study GREM1 methylation in clear cell renal cell carcinoma (ccRCC) and its impact on tumor characteristics and clinical outcome...

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Autori principali: van Vlodrop, Iris J.H., Baldewijns, Marcella M.L., Smits, Kim M., Schouten, Leo J., van Neste, Leander, van Criekinge, Wim, van Poppel, Hein, Lerut, Evelyne, Schuebel, Kornel E., Ahuja, Nita, Herman, James G., de Bruïne, Adriaan P., van Engeland, Manon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808066/
https://ncbi.nlm.nih.gov/pubmed/20042676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090442
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