Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a panel of primary human colorectal cancer samples, we...

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Detalhes bibliográficos
Main Authors: Schuebel, Kornel E, Chen, Wei, Cope, Leslie, Glöckner, Sabine C, Suzuki, Hiromu, Yi, Joo-Mi, Chan, Timothy A, Neste, Leander Van, Criekinge, Wim Van, van den Bosch, Sandra, van Engeland, Manon, Ting, Angela H, Jair, Kamwing, Yu, Wayne, Toyota, Minoru, Imai, Kohzoh, Ahuja, Nita, Herman, James G, Baylin, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988850/
https://ncbi.nlm.nih.gov/pubmed/17892325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030157
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