Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

In this report, we show that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron transport chain activates the three major pathways of hyperglycemic damage found in aortic endothelial cells by inhibiting GAPDH activity. In bovine aortic endothelial cells, GAPDH antisense...

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Main Authors: Du, Xueliang, Matsumura, Takeshi, Edelstein, Diane, Rossetti, Luciano, Zsengellér, Zsuzsanna, Szabó, Csaba, Brownlee, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC198524/
https://ncbi.nlm.nih.gov/pubmed/14523042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318127
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