Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications

This study evaluated the effects of aldose reductase inhibition on diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal experiments, control and streptozotocin-induced diabetic rats were treated with or without the aldose reductase inhibitor (ARI...

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Main Authors: Obrosova, Irina G., Pacher, Pal, Szabó, Csaba, Zsengeller, Zsuzsanna, Hirooka, Hiroko, Stevens, Martin J., Yorek, Mark A.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756473/
https://ncbi.nlm.nih.gov/pubmed/15616034
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