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Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells

Both increased aldose reductase (AR) activity and oxidative/nitrosative stress have been implicated in the pathogenesis of diabetic nephropathy, but the relation between the two factors remains a subject of debate. This study evaluated the effects of AR inhibition on nitrosative stress and poly(ADP-...

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Detalhes bibliográficos
Main Authors: Drel, Viktor R., Pacher, Pal, Stevens, Martin J., Obrosova, Irina G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225484/
https://ncbi.nlm.nih.gov/pubmed/16631535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2005.12.034
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