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Structure-Based Dissociation of a Type I Polyketide Synthase Module

Individual catalytic modules of modular polyketide synthases (PKSs) such as the 6-deoxyerythronolide B synthase (DEBS) are comprised of highly conserved, covalently linked domains separated by relatively unconserved intervening sequences known as linkers. Recent structural studies have provided the...

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Autors principals: Chen, Alice Y., Cane, David E., Khosla, Chaitan
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978548/
https://ncbi.nlm.nih.gov/pubmed/17656315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.05.015
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