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Effects of pyrrophenone, an inhibitor of group IVA phospholipase A(2), on eicosanoid and PAF biosynthesis in human neutrophils
BACKGROUND AND PURPOSE: The biosynthesis of leukotrienes (LT) and platelet-activating factor (PAF) involves the release of their respective precursors, arachidonic acid (AA) and lyso-PAF by the group IVA PLA(2) (cPLA(2)α). This paper aims at characterizing the inhibitory properties of the cPLA(2)α i...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1978440/ https://ncbi.nlm.nih.gov/pubmed/16967052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706879 |
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