Inherited human group IVA cytosolic phospholipase A(2) deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

Eicosanoids are important vascular regulators, but the phospholipase A(2) (PLA(2)) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-f...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Kirkby, Nicholas S., Reed, Daniel M., Edin, Matthew L., Rauzi, Francesca, Mataragka, Stefania, Vojnovic, Ivana, Bishop-Bailey, David, Milne, Ginger L., Longhurst, Hilary, Zeldin, Darryl C., Mitchell, Jane A., Warner, Timothy D.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608906/
https://ncbi.nlm.nih.gov/pubmed/26183771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275065
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