Inherited human group IVA cytosolic phospholipase A(2) deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

Eicosanoids are important vascular regulators, but the phospholipase A(2) (PLA(2)) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-f...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Kirkby, Nicholas S., Reed, Daniel M., Edin, Matthew L., Rauzi, Francesca, Mataragka, Stefania, Vojnovic, Ivana, Bishop-Bailey, David, Milne, Ginger L., Longhurst, Hilary, Zeldin, Darryl C., Mitchell, Jane A., Warner, Timothy D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2016
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4608906/
https://ncbi.nlm.nih.gov/pubmed/26183771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275065
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