Lymphocytes genetically modified to express tumor antigens target DCs in vivo and induce antitumor immunity

The exploitation of the physiologic processing and presenting machinery of DCs by in vivo loading of tumor-associated antigens may improve the immunogenic potential and clinical efficacy of DC-based cancer vaccines. Here we show that lymphocytes genetically modified to express self/tumor antigens, a...

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Détails bibliographiques
Auteurs principaux: Russo, Vincenzo, Cipponi, Arcadi, Raccosta, Laura, Rainelli, Cristina, Fontana, Raffaella, Maggioni, Daniela, Lunghi, Francesca, Mukenge, Sylvain, Ciceri, Fabio, Bregni, Marco, Bordignon, Claudio, Traversari, Catia
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978420/
https://ncbi.nlm.nih.gov/pubmed/17885685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30605
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