24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development

Cells in the tumor microenvironment may be reprogrammed by tumor-derived metabolites. Cholesterol-oxidized products, namely oxysterols, have been shown to favor tumor growth directly by promoting tumor cell growth and indirectly by dampening antitumor immune responses. However, the cellular and mole...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Soncini, Matias, Corna, Gianfranca, Moresco, Marta, Coltella, Nadia, Restuccia, Umberto, Maggioni, Daniela, Raccosta, Laura, Lin, Chin-Yo, Invernizzi, Francesca, Crocchiolo, Roberto, Doglioni, Claudio, Traversari, Catia, Bachi, Angela, Bernardi, Rosa, Bordignon, Claudio, Gustafsson, Jan-Åke, Russo, Vincenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068323/
https://ncbi.nlm.nih.gov/pubmed/27671648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613332113
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