Re-wired ERK-JNK signaling pathways in melanoma

Constitutive activation of MEK-ERK signaling is often found in melanomas. Here, we identify a mechanism that links ERK with JNK signaling in human melanoma. Constitutively active ERK increases c-Jun transcription and stability, which are mediated by CREB and GSK3, respectively. Subsequently, c-Jun i...

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Autores principales: Lopez-Bergami, Pablo, Huang, Conway, Goydos, James S., Yip, Dana, Bar-Eli, Menashe, Herlyn, Meenhard, Smalley, Keiran S. M., Mahale, Alka, Eroshkin, Alexey, Aaronson, Stuart, Ronai, Ze’ev
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978100/
https://ncbi.nlm.nih.gov/pubmed/17482134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.03.009
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