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Identification of a tumour suppressor network opposing nuclear Akt function
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor1. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation. Yet many targets inhibited by phosphorylated AKT (for example, the FOX...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976603/ https://ncbi.nlm.nih.gov/pubmed/16680151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04809 |
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