mTOR Promotes Survival and Astrocytic Characteristics Induced by Pten/Akt Signaling in Glioblastoma

Combined activation of Ras and Akt leads to the formation of astrocytic glioblastoma multiforme (GBM) in mice. In human GBMs, AKT is not mutated but is activated in approximately 70% of these tumors, in association with loss of PTEN and/or activation of receptor tyrosine kinases. Mechanistic justifi...

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Hlavní autoři: Hu, Xiaoyi, Pandolfi, Pier Paolo, Li, Yi, Koutcher, Jason A, Rosenblum, Marc, Holland, Eric C
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2005
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501155/
https://ncbi.nlm.nih.gov/pubmed/15967113
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