Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge

Pharmacologic infusion of activated protein C (APC) improves survival in severe sepsis, and platelet factor 4 (PF4) accelerates APC generation in a primate thrombin-infusion model. We now tested whether endogenous platelet PF4 content affects APC generation. Mice completely deficient in PF4 (mPF4(−/...

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Main Authors: Kowalska, M. Anna, Mahmud, Shawn A., Lambert, Michele P., Poncz, Mortimer, Slungaard, Arne
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Hemostasis, Thrombosis, and Vascular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976343/
https://ncbi.nlm.nih.gov/pubmed/17540840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-081901
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