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Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets

Cofilin is a regulator of actin filament dynamics. We studied whether during platelet activation Rho kinase stimulates LIM kinase (LIMK) leading to subsequent phosphorylation and inactivation of cofilin. Platelet shape change and aggregation/secretion were induced by low and high concentrations of t...

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Autors principals: Pandey, Dharmendra, Goyal, Pankaj, Bamburg, James R., Siess, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895613/
https://ncbi.nlm.nih.gov/pubmed/16219803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4377
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