Depletion of GGA3 stabilizes BACE and enhances β-secretase activity

Beta-site APP-cleaving enzyme (BACE) is required for production of the Alzheimer's disease (AD)-associated Aβ protein. BACE levels are elevated in AD brain, and increasing evidence reveals BACE as a stress-related protease that is upregulated following cerebral ischemia. However, the molecular...

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Bibliografiske detaljer
Main Authors: Tesco, Giuseppina, Koh, Young Ho, Kang, Eugene, Cameron, Andrew, Das, Shinjita, Sena-Esteves, Miguel, Hiltunen, Mikko, Yang, Shao-Hua, Zhong, Zhenyu, Shen, Yong, Simpkins, James, Tanzi, Rudolph E.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973166/
https://ncbi.nlm.nih.gov/pubmed/17553422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.05.012
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