BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

BACKGROUND: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous studies have shown that the clathrin adaptor Golgi-localized...

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Publicat a:Mol Neurodegener
Autors principals: Kim, WonHee, Ma, Liang, Lomoio, Selene, Willen, Rachel, Lombardo, Sylvia, Dong, Jinghui, Haydon, Philip G., Tesco, Giuseppina
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796504/
https://ncbi.nlm.nih.gov/pubmed/29391027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0239-7
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