BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

BACKGROUND: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous studies have shown that the clathrin adaptor Golgi-localized...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Kim, WonHee, Ma, Liang, Lomoio, Selene, Willen, Rachel, Lombardo, Sylvia, Dong, Jinghui, Haydon, Philip G., Tesco, Giuseppina
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796504/
https://ncbi.nlm.nih.gov/pubmed/29391027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0239-7
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires